All AbMole products are for research use only, cannot be used for human consumption.
BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC). BT2 is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM.
| Molecular Weight | 247.1 |
| Formula | C9H4Cl2O2S |
| CAS Number | 34576-94-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL (ultrasonic) |
| Storage | Powder -20°C |
[5] Zhen Li, et al. Circ Res. Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure
| Related Bcl-2 Products |
|---|
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ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). |
| WEHI-539
WEHI-539 is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM. |
| (Rac)-Lisaftoclax
(Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be uesd for hematologic malignancy research. |
| BcI-2/BcI-xI ligand 1
BcI-2/BcI-xI ligand 1 is a BcI-2/BcI-xI ligand, and can be used for synthesis of PROTAC BcI-2/BcI-xI Degrader-1. |
| AZD-5991 (S-enantiomer)
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. |
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Products are for research use only. Not for human use. We do not sell to patients.
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