About 8 results found for searched term "Bcl-2" (0.053 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M13532 | S55746 | Bcl-2 |
| BCL201 | ||
| S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity. | ||
| M13533 | S55746 hydrochloride | Bcl-2 |
| BCL201 hydrochloride | ||
| S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity. | ||
| M22479 | Lisaftoclax | Bcl-2 |
| APG-2575; Bcl-2/Bcl-xl inhibitor 1 | ||
| Lisaftoclax (APG-2575) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. | ||
| M28068 | A-1211212 | Bcl-2 |
| BCL2-IN-1 | ||
| A-1211212 (BCL2-IN-1) is a potent Bcl-2 inhibitor. BCL2-IN-1 binds Bcl-2 with a Ki of <0.01 nM. | ||
| M29577 | PROTAC Bcl2 degrader-1 | PROTAC |
| PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. | ||
| M41317 | Bcl-2-IN-11 | Bcl-2 |
| Bcl-2-IN-11 is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. | ||
| M41436 | CDK2/Bcl2-IN-1 | CDK |
| CDK2/Bcl2-IN-1 with promising cytotoxicity against cancer cells. | ||
| M58115 | Recombinant Human Bcl-2 Protein (E. coli, C-His) | Cytokines and Growth Factors |
| B-cell leukemia/lymphoma 2 | ||
| B-cell leukemia/lymphoma 2, also known as Bcl-2, belongs to the Bcl-2 family. BCL2 blocks the apoptotic death of some cells such as lymphocytes. It also regulates cell death by controlling the mitochondrial membrane permeability and inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. | ||
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