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Bax inhibitor peptide V5

Cat. No. M9419
Bax inhibitor peptide V5 Structure

BAX Inhibiting Peptide V5; BIP-V5

Size Price Availability Quantity
10mg USD 155  USD155 In stock
50mg USD 555  USD555 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Bax inhibitor peptide V5 is a membrane-permeable peptide inhibitor of Bax translocation to mitochondria. In HeLa cells, BIP V5 protected cells from UVC- and STS-induced apoptosis. In U87-MG glioma cells, MCF-7 breast cancer cells and LNCaP prostate cancer cells, BIP V5 also inhibited apoptosis induced by anti-cancer compounds cisplatin, etoposide and doxorubicin. In a mouse model, BIP V5 increased expression of anti-apoptotic proteins XIAP and Bcl-2 by more than 11- and 3-fold and reduced expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κ B-p65 by 10, 30, and nearly 50%, respectively. BIP-V5 (100 μM) also significantly improves islet function following isolation and improves islet graft function following transplantation in mice model.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 586.79
Formula C27H50N6O6S
CAS Number 579492-81-2
Purity >99%
Solubility DMSO ≥ 27 mg/mL
Storage at -20°C

[1] Rivas-Carrillo JD, et al. Diabetes. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice.

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Keywords: Bax inhibitor peptide V5, BAX Inhibiting Peptide V5; BIP-V5 supplier, Bcl-2, inhibitors

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