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Bax inhibitor peptide V5

Cat. No. M9419
Bax inhibitor peptide V5 Structure
Synonym:

BAX Inhibiting Peptide V5; BIP-V5

Size Price Availability Quantity
10mg USD 155  USD155 In stock
50mg USD 555  USD555 In stock
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Quality Control & Documentation
Biological Activity

Bax inhibitor peptide V5 is a membrane-permeable peptide inhibitor of Bax translocation to mitochondria. In HeLa cells, BIP V5 protected cells from UVC- and STS-induced apoptosis. In U87-MG glioma cells, MCF-7 breast cancer cells and LNCaP prostate cancer cells, BIP V5 also inhibited apoptosis induced by anti-cancer compounds cisplatin, etoposide and doxorubicin. In a mouse model, BIP V5 increased expression of anti-apoptotic proteins XIAP and Bcl-2 by more than 11- and 3-fold and reduced expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κ B-p65 by 10, 30, and nearly 50%, respectively. BIP-V5 (100 μM) also significantly improves islet function following isolation and improves islet graft function following transplantation in mice model.

Chemical Information
Molecular Weight 586.79
Formula C27H50N6O6S
CAS Number 579492-81-2
Solubility (25°C) DMSO ≥ 27 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rivas-Carrillo JD, et al. Diabetes. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice.

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Keywords: Bax inhibitor peptide V5, BAX Inhibiting Peptide V5; BIP-V5 supplier, Bcl-2, inhibitors, activators


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