| Cat.No. | Name | Information |
|---|---|---|
| M1637 | ABT-263 | ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w. |
| M2017 | ABT-199 (Venetoclax) | ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor. ABT-199 is the first inhibitor targeting Bcl-2 and PPI. |
| M5273 | S63845 | S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM. |
| M13528 | AZD-5991 | AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay. |
| M13526 | A-1155463 | A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 of 70 nM in Molt-4 cell. |
| M6256 | BTSA1 | BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells. |
| M5266 | BH3I-1 | BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins. |
| M5226 | UMI-77 | UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family. |
| M4932 | A-1210477 | A-1210477 is A potent, selective McL-1 inhibitor with A Ki value of 0.45 nM. A-1210477 specifically binds TO McL-1 and promotes apoptosis in A McL-1 dependent manner. |
| M4775 | Gambogic-acid | Gambogic Acid (beta-Guttiferrin) a Gambogic resin from the Garcinia Hanburyi tree. Gambogic Acid (beta-guttiferrin) inhibited bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and McL-1 with IC50 values of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, respectively. 1.06 μM and 0.79 μM. |
| M4637 | Jaceosidin | Jaceosidin is a flavonoid obtained from Artemisia vestita, which can activate Bax, down-regulate the expression of McL-1 and C-flip, and induce apoptosis of cancer cells. Jaceosidin has anti-cancer and anti-inflammatory effects, which can reduce the level of inflammatory factors, activate NF-κB, and inhibit the expression of COX-2. |
| M4521 | Dehydrocorydaline | Dehydrocorydaline is an alkaloid, it can regulate protein expression of Bax, Bcl-2. Dehydrocorydaline elevates p38 MAPK activation. |
| M4386 | Gossypol Acetate (Gossypol Acetic Acid) | Gossypol Acetate (Gossypol Acetic Acid) was combined with Bcl-XL and Bcl-2 proteins with Ki values of 0.5-0.6 μM and 0.2-0.3 mM, respectively. |
| M4385 | Gossypol | Gossypol has been known to exert a potential for anti-cancer, anti-inflammatory and other important therapeutic activities, gossypol binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins. |
| M4320 | Koumine | Koumine is an alkaloid obtained from Gelsemium elegans, which has high anti-tumor activity and can increase the protein ratio of Bax/Bcl-2 and the expression of Caspase-3 in tumor cells. Koumine has anti-anxiety, anti-stress, and anti-psoriasis activities and can also be used in pain relief studies. In animal models of rheumatoid arthritis, Koumine was able to prevent the development of arthritis. |
| M3757 | Obatoclax Mesylate | Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-XL, and Mcl-1 (KD = ~500 nM). |
| M3753 | HA14-1 | HA14-1 is a Bcl-2 inhibitor that is widely used for studies of apoptosis with IC50 of ~9 μM. |
| M2992 | Sabutoclax | Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. |
| M2460 | BM-1074 | BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM, inactive to Mcl-1. |
| M2430 | BAM7 | BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM. |
| M2401 | Apogossypolone | Apogossypolone (ApoG2) is a pan Bcl-2 inhibitor for Bcl-2, Bcl-XL and Mcl-1 with Ki of 35 nM, 660 nM and 25 nM, respectively. |
| M2314 | TW-37 | TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. |
| M1860 | AT-101 | AT-101 (R-(-)-gossypol acetic acid) is a pan small molecule inhibitor of Bcl-2, Bcl-xL, and Mcl-1. |
| M1638 | ABT-737 | ABT-737 is a potent and selective inhibitor of B-cell lymphoma-2 (BCL-2) family proteins, in small cell lung cancer. |
| M54332 | BAD (103-127) (human) | BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL. |
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