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Dehydrocorydaline

Cat. No. M4521
Dehydrocorydaline Structure
Size Price Availability Quantity
1mg USD 58  USD58 In stock
5mg USD 140  USD140 In stock
10mg USD 200  USD200 In stock
20mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Dehydrocorydaline is an alkaloid, it can regulate protein expression of Bax, Bcl-2. Dehydrocorydaline elevates p38 MAPK activation. Dehydrocorydaline significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. Dehydrocorydaline (0-200 μM)dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.

Chemical Information
Molecular Weight 366.43
Formula C22H24NO4+
CAS Number 30045-16-0
Solubility (25°C) DMSO 40 mg/mL
Soluble in acidic solution
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Onco Targets Ther. Erratum: Dehydrocorydaline Inhibits Cell Proliferation, Migration and Invasion via Suppressing MEK1/2-ERK1/2 Cascade in Melanoma [Corrigendum]

[2] Yadong Li, et al. Dehydrocorydaline Protects Against Sepsis-Induced Myocardial Injury Through Modulating the TRAF6/NF-κB Pathway

[3] Xiangpeng Kong, et al. Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage

[4] Ying Huang, et al. Dehydrocorydaline inhibits the tumorigenesis of breast cancer MDA‑MB‑231 cells

[5] Lisha Jin, et al. Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters

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Bax inhibitor peptide, negative control

Bax inhibitor peptide, negative control is a inhibitor of Bax.

Bad BH3 (mouse)

Bad BH3 (mouse) is a biological active peptide.

Bid BH3 (80-99)

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Keywords: Dehydrocorydaline supplier, Bcl-2, inhibitors, activators


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