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BDA-366 is a BCL2 BH4 domain antagonist, that binds BH4 with high affinity and selectivity. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without significant cytotoxic effects on normal hematopoietic cells or body weight. Combined BDA-366 and RAD001 treatment exhibits strong synergy against lung cancer in vivo.
| Molecular Weight | 423.51 |
| Formula | C24H29N3O4 |
| CAS Number | 1821496-27-8 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Han B, et al. Cancer Cell. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy.
[2] Deng J, et al. Oncotarget. BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth.
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