Free shipping on all orders over $ 500

Koumine

Cat. No. M4320

All AbMole products are for research use only, cannot be used for human consumption.

Koumine Structure
Size Price Availability Quantity
20mg USD 320  USD320 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Koumine is an alkaloid obtained from Gelsemium elegans, which has high anti-tumor activity and can increase the protein ratio of Bax/Bcl-2 and the expression of Caspase-3 in tumor cells. Koumine has anti-anxiety, anti-stress, and anti-psoriasis activities and can also be used in pain relief studies. In animal models of rheumatoid arthritis, Koumine was able to prevent the development of arthritis.

Chemical Information
Molecular Weight 306.40
Formula C20H22N2O
CAS Number 1358-76-5
Form Solid
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Yarong Lin, et al. The immunomodulatory effect of koumine on B cells under dependent and independent responses by T cells

[2] Bojun Xiong, et al. Identification of Koumine as a Translocator Protein 18 kDa Positive Allosteric Modulator for the Treatment of Inflammatory and Neuropathic Pain

[3] Jing Wu, et al. Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF- κB Pathway

[4] Zi-Yuan Wang, et al. The Metabolism and Disposition of Koumine, Gelsemine and Humantenmine from Gelsemium

[5] Gui-Lin Jin, et al. Koumine Attenuates Neuroglia Activation and Inflammatory Response to Neuropathic Pain

Related Bcl-2 Products
ABBV-467 

ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM).

WEHI-539 

WEHI-539 is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM.

(Rac)-Lisaftoclax

(Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be uesd for hematologic malignancy research.

BcI-2/BcI-xI ligand 1 

BcI-2/BcI-xI ligand 1 is a BcI-2/BcI-xI ligand, and can be used for synthesis of PROTAC BcI-2/BcI-xI Degrader-1.

AZD-5991 (S-enantiomer) 

AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991.

  Catalog
Abmole Inhibitor Catalog




Keywords: Koumine supplier, Bcl-2, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.