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Sonrotoclax

Cat. No. M45050

All AbMole products are for research use only, cannot be used for human consumption.

Sonrotoclax Structure
Synonym:

BGB 11417

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Quality Control & Documentation
Biological Activity

Sonrotoclax is an orally active, potent Bcl2 inhibitor.Sonrotoclax exhibits potent cell killing effects on a variety of lymphoma and leukemia cell lines. Sonrotoclax is effective in killing a variety of lymphoma and leukemia cell lines and may be used in studies related to hematologic tumors.

Chemical Information
Molecular Weight 890.10
Formula C49H59N7O7S
CAS Number 2383086-06-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yunhang Guo, et al. J Med Chem. Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2

[2] Antonella Bruzzese, et al. Expert Opin Investig Drugs. Potential of BGB-11417, a BCL2 inhibitor, in hematological malignancies

[3] Jiuyang Liu, et al. Blood. Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy

[4] Shayna Sarosiek, et al. Drugs. Waldenström Macroglobulinemia: Targeted Agents Taking Center Stage

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  Catalog
Abmole Inhibitor Catalog




Keywords: Sonrotoclax, BGB 11417 supplier, Bcl-2, inhibitors, activators

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