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(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
| Molecular Weight | 578.61 |
| CAS Number | 866541-93-7 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related Bcl-2 Products |
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| ABBV-467
ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). |
| WEHI-539
WEHI-539 is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM. |
| (Rac)-Lisaftoclax
(Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be uesd for hematologic malignancy research. |
| BcI-2/BcI-xI ligand 1
BcI-2/BcI-xI ligand 1 is a BcI-2/BcI-xI ligand, and can be used for synthesis of PROTAC BcI-2/BcI-xI Degrader-1. |
| AZD-5991 (S-enantiomer)
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. |
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