About 16 results found for searched term "XY-52" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M27770 | Nemorubicin | DNA/RNA Synthesis |
| Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243 | ||
| Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity. | ||
| M42924 | XY-52 | Others |
| XY-52 is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 5.68 μM in AlphaLISA assay, and 4.59 μM in HEK-Blue assay. | ||
| M56885 | 6-Carboxy-JF5252 | Fluorescent Dye |
| 6-Carboxy-JF5252 is a fluorophore. | ||
| M3367 | CAY10505 | PI3K |
| CAY10505 is dehydroxyl of AS-252424, which is a PI3Kγ inhibitor with IC50 of 33 nM. | ||
| M4058 | 11-oxo-mogroside-V | ROS |
| 11-Oxo-Mogroside V is a natural sweetener with strong antioxidant activity. 11-OXo-Mogroside V had a significant inhibitory effect on reactive oxygen species, and the EC50 of O2-, H2O2 and *OH were 4.79, 16.52 and 146.17 μg/mL, respectively. | ||
| M4447 | 3-Hydroxy-4-methoxycinnamic-acid | Adrenergic Receptor |
| 3-Hydroxy-4-methoxycinnamic acid | ||
| Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a kind of cinnamic acid derivative with anti - diabetes activity. Isoferulic acid (3-hydroxy-4-methoxycinnamic acid) binds and activates α 1-adrenergic receptor (IC50=1.4 μM), Enhanced β -endorphin secretion (EC50=52.2 nM) and increased in vitro glucose use. Isoferulic acid also has activity against influenza virus. | ||
| M9096 | H2DCFDA | Fluorescent Dye |
| DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate | ||
| H2DCFDA is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm). H2DCFDA can be used for the Bacterial reactive oxygen species (ROS) production assay. | ||
| M14664 | BVT-14225 | Hydroxysteroid dehydrogenase |
| BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM. | ||
| M20864 | L-2-Hydroxyglutaric acid disodium | Histone demethylase |
| (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG | ||
| L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively. | ||
| M21709 | 5-FAM | Fluorescent Dye |
| 5-Carboxyfluorescein; 5-CF | ||
| 5-FAM (5-Carboxyfluorescein) is a green fluorescent reagent used for in situ labeling peptides, proteins and nucleotides. 5-FAM is a single isomer with Ex/Em of 490 nm/520 nm. | ||
| M29289 | 6-Hydroxy-DOPA | DNA/RNA Synthesis |
| 6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer. | ||
| M29571 | HM Janelia Fluor 526, SE | Fluorescent Dye |
| HM-JF526 NHS | ||
| HM Janelia Fluor 526, SE (HM-JF526 NHS) is a derivative of hydroxymethyl JF526 (HM-JF526). SMLM (single-molecule localization microscopy) imaging in standard phosphate-buffered saline (pH 7.4) revealed that the HM-JF526 label showed spontaneous blinking behavior throughout the imaging session and did not require short-wavelength activation light. | ||
| M30740 | Fostemsavir Tris | HIV Protease |
| BMS-663068 Tris | ||
| Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl proagent of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells. | ||
| M40799 | 1,3-Diphenylisobenzofuran | Fluorescent Dye |
| DPBF | ||
| 1,3-Diphenylisobenzofuran is a selective fluorescent probe that reacts highly specifically with a number of reactive oxygen species (e.g., singlet oxygen and hydroxyl, alkyl oxygen, or alkyl peroxy radicals), and can be used for the quantitative detection of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS), (λex=495 nm, λem=523 nm). | ||
| M49483 | B-355252 | Apoptosis |
| B-355252 is a phenoxythiophene sulfonamide small molecule and a potent NGF receptor agonist that enhances NGF-induced neurite growth. It also protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and LDH levels, and preventing neuronal apoptosis. In addition, B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity and in a mouse hippocampal cell line (HT22) model of Parkinson's disease (PD). | ||
| M54186 | pp60 c-src (521-533) (phosphorylated) | Others |
| pp60 c-src (521-533) (phosphorylated) is a peptide corresponding to the pp60c-src carboxy terminal regulatory domain, phosphorylated at Tyr527. | ||
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