1,3-Diphenylisobenzofuran is a selective fluorescent probe that reacts highly specifically with a number of reactive oxygen species (e.g., singlet oxygen and hydroxyl, alkyl oxygen, or alkyl peroxy radicals), and can be used for the quantitative detection of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS), (λex=495 nm, λem=523 nm).
| Molecular Weight | 270.33 |
| Formula | C20H14O |
| CAS Number | 5471-63-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 5.56 mg/mL |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] René T Boeré et al. Acta Crystallogr Sect E Struct Rep Online. 1,3-diphenylisobenzofuran
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