Indocyanine Green (Cardiogreen) is an FDA-approved cyanine dye used in medical diagnosis. Used to measure cardiac output and liver function, hepatic blood flow, and ophthalmic angiography.
Exp Eye Res. 2023 Apr 18;231:109474.
Inhibition of AIF-1 alleviates laser-induced macular neovascularization by inhibiting endothelial cell proliferation via restrained p44/42 MAPK signaling pathway
Indocyanine green purchased from AbMole
SSRN. 2022 Apr.
Inhibition of TREM-1 Alleviates Choroidal Neovascularization in a Mouse Model
Indocyanine green purchased from AbMole
| Molecular Weight | 774.96 |
| Formula | C43H47N2NaO6S2 |
| CAS Number | 3599-32-4 |
| Solubility (25°C) | DMSO 30 mg/mL Water 10 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Gianluca Cassese, et al. Indocyanine green applications in hepato-biliary surgery
[2] Bogdan Petrut, et al. Indocyanine green use in Urology
[3] S Houthoofd, et al. Photodynamic therapy for atherosclerosis. The potential of indocyanine green
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