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B-355252 is a phenoxythiophene sulfonamide small molecule and a potent NGF receptor agonist that enhances NGF-induced neurite growth. It also protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and LDH levels, and preventing neuronal apoptosis. In addition, B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity and in a mouse hippocampal cell line (HT22) model of Parkinson's disease (PD).
| Molecular Weight | 514.06 |
| Formula | C25H24ClN3O3S2 |
| CAS Number | 1261576-81-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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