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L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.
| Molecular Weight | 192.08 |
| Formula | C5H6Na2O5 |
| CAS Number | 63512-50-5 |
| Solubility (25°C) | Water 38 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Histone demethylase Products |
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PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. |
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CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. |
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| Zavondemstat L-lysine
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Products are for research use only. Not for human use. We do not sell to patients.
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