About 32 results found for searched term "XT-4" (0.074 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9390 | FITC-Dextran (MW 4000) | Fluorescent Dye |
| FITC-Dextran is a marker consisting of coupling fluorescein-isothiocyanate to dextran. FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption. | ||
| M9543 | Dextran (Mw 40000) | Others |
| Dextran (Dextran 40000) has an inhibitory effect on thrombocyte aggregation. | ||
| M21428 | FITC-Dextran (MW 40000) | Fluorescent Dye |
| FITC-Dextran is a marker consisting of coupling fluorescein-isothiocyanate to dextran. | ||
| M53544 | XT-4 | Antibiotic |
| XT-4 is an antimicrobial peptide derived from skin secretions of Xenopus tropicalis. | ||
| M1849 | Voxtalisib (XL765) | PI3K |
| SAR245409 | ||
| Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2. | ||
| M2191 | Forskolin | Adenylate Cyclase |
| Coleonol; Colforsin; HL 362 | ||
| Forskolin is a diterpenoid natural product extracted from the hairy throat sphagnum flower (Coleus forskohlii), and is also a eukaryotic adenylate cyclase (AC) activator, which can increase cAMP levels. In addition, Forskolin can be used as a substitute for Oct4 in the induction and maintenance of pluripotent stem cells in mice and promotes osteoblast differentiation in vitro with potential anti-osteoporotic activity. | ||
| M2428 | BAF312 | S1P Receptor |
| Siponimod | ||
| BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. | ||
| M4085 | Ginsenoside-F3 | IL Receptor/Related |
| Ginsenoside F3, a saponin extracted from Panax ginseng leaves, exerts immune-enhancing activity by regulating the production and expression of il-2 (IFN-γ) and IL-4 and IL-10. | ||
| M4191 | Polygalaxanthone-III | Cytochrome P450 (e.g. CYP17) |
| Polygalaxanthone III was extracted from Polygala Tenuifolia Wild and had inhibitory effects on CYP450. Polygalaxanthone III inhibited the 6-hydroxylation of clozoxazone catalyzed by CYP2E1 with IC50 of 50.56μM. | ||
| M4303 | Khasianine | Others |
| Khasianine is a steroid sugar alkaloid. It is a natural product extracted from Solanum Nigrum L, a solanum plant, and has strong activity against CCl4 induced liver injury. It has anti-tumor activity. | ||
| M4391 | Isoimperatorin | AChR/AChE |
| Isoimperatorin is a methanol extract from the root of Angelica dahurica. It effectively inhibits acetylcholinesterase (AChE) with IC50 of 74.6 μM. | ||
| M4539 | Polygalasaponin-F | TLR |
| Polygalasaponin F is an oleanane type triterpenoid saponin extracted from Polygala Japonica, which can reduce the release of inflammatory cytokine tumor necrosis factor α (TNFa). Polygalasaponin F reduces the secretion of neuroinflammatory cytokines by regulating the TLR4-PI3K/ Akt-NF-KB signaling pathway. | ||
| M4594 | Cytisine | AChR/AChE |
| Cytisine; Sophorine; Baptitoxine | ||
| Cytisinicline (Cytisine) is an alkaloid that can be extracted from Laburnum and Cytisus. Cytisinicline (Cytisine) is a partial agonist of α4β2 nicotinic acetylcholinergic receptors (α4β2 nAChRs), and also a partial agonist of α4β2 and α7 receptors. It has been used medically to help people quit smoking. | ||
| M4621 | Garcinone-C | ATM/ATR |
| Garcinone C is a xanthone derivative, a natural compound extracted from Garcinia oblongifolia Champ. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while effectively inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, CDC2, Stat3 and CDK7. | ||
| M5117 | CFDA-SE | Fluorescent Dye |
| CFSE; 5(6)-Carboxyfluorescein diacetate succinimidyl ester; 5(6)-CFDA N-succinmidyl ester | ||
| Succinimide (CFSE) is a luciferase - based tracer that penetrates and immobilizes cells for extremely long-term cell labeling. The maximum excitation/emission wavelength is 494nm/521 nm. Fluorescent green. Store away from light. | ||
| M5272 | Bioymifi | TNF Receptor |
| DR5 Activator | ||
| Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis. | ||
| M6218 | Trastuzumab | EGFR/HER2 |
| Herceptin | ||
| Trastuzumab is a humanized, recombinant monoclonal antibody that binds to the extracellular domain of HER2, MW:145.53 KD. | ||
| M8938 | FIIN-3 | FGFR |
| FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor with IC50 values of 13.1, 21, 31.4 and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. | ||
| M9346 | Pralsetinib | RET |
| BLU-667 | ||
| Pralsetinib (BLU-667) is a next generation highly potent, selective RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. | ||
| M10396 | Deruxtecan | Drug-Linker Conjugates for ADC |
| Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. | ||
| M10374 | AMG 232 | Mdm2 |
| Navtemadlin ; KRT-232 | ||
| AMG 232 is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg). *The compound is unstable in solutions, freshly prepared is recommended | ||
| M10388 | (+)-JQ1 PA | Epigenetic Reader Domain |
| (+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1 with IC50 of 10.4 nM. | ||
| M10572 | Paeonol | Monoamine Oxidase |
| Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively. | ||
| M10743 | GNE-140 racemate | LDH |
| GNE-140 racemate is a racemic mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is also a potent lactate dehydrogenase A (LDHA) inhibitor. | ||
| M10772 | AB-680 | Immunology/Inflammation |
| AB-680 is a potent, reversible, selective CD73 (extracellular nucleotide enzyme) inhibitor of hCD73 Ki The value is 4.9 pM, which is more than 10,000 times more selective than the associated extracellular nucleotide CD39. Has antitumor activity. | ||
| M10878 | Reldesemtiv | Others |
| CK-2127107 | ||
| Reldesemtiv (CK-2127107) is a selective, orally active next-generation rapid skeletal muscle troponin activator (FSTA). Reldesemtiv selectively activates rapid skeletal muscle fibrils, EC50Is 3.4 μM. | ||
| M10974 | 3,4-Dimethoxycinnamic acid | ROS |
| O-Methylferulic acid | ||
| 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata. 3,4-Dimethoxycinnamic acid exerts an anti-apoptotic effect on L-02 cells through a ROS-mediated signaling pathway. | ||
| M11075 | Scutellarein tetramethyl ether | Antibiotic |
| 4',5,6,7-Tetramethoxyflavone | ||
| Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive ingredient found in Siamese grass extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exerts anti-inflammatory activity through the NF-κB pathway. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulates bacterial resistance through outflow pump inhibition. | ||
| M11481 | Abatacept | Immunology/Inflammation |
| Orencia；CTLA4lg；BMS-188667 | ||
| Abatacept is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1. Abatacept binds to antigen presenting cells CD80 and CD86, blocks costimulatory signals and inhibits T cell activation, and is used in the study of rheumatoid arthritis and juvenile rheumatoid arthritis. | ||
| M13748 | Gap 26 TFA | Others |
| Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif. | ||
| M13889 | CL 316243 | Adrenergic Receptor |
| CL316243 | ||
| CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors.CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. | ||
| M14882 | Ibrutinib-biotin | BTK |
| Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK. | ||
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