About 21 results found for searched term "ULK" (0.121 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10323 | ULK-101 | ULK |
| ULK101 | ||
| ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM. | ||
| M10087 | Ginkgolide K | Autophagy |
| Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. | ||
| M5043 | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | Others |
| 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate, which is widely used in the synthesis of many pharmaceutical intermediates at home and abroad. Including CP690550, CGP76030 and so on, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the scaffold for many commercially available drugs. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response. | ||
| M6086 | SBI-0206965 | ULK |
| SBI 0206965; SBI0206965 | ||
| SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 . | ||
| M8666 | Urolithin A | ERK |
| Urolithin A is a naturally occurring compound produced by the metabolism in the body of vegetable tannins (ellagic acid and ellagitannins) found in food. It is also a mitochondrial modulator, regulating mitochondrial function in hematopoietic stem cells, as well as restoring blood regeneration in aging hematopoietic stem cells. In addition, Urolithin A is a ligand for the Aromatic Hydrocarbon Receptor (AhR), which promotes the anti-tumor function of CD8+ cytotoxic T-lymphocytes (CTLs) in an AhR-independent manner. Moreover, Urolithin A directly binds to ERK1/2 kinase, enhances its activation, and subsequently phosphorylates and activates the autophagy initiation factor ULK1, thereby promoting autophagy. | ||
| M9851 | GW406108X | Autophagy |
| GW108X | ||
| GW406108X is a potent autophagy inhibitor, with a pIC50 6.37 (427 nM) against ULK1. | ||
| M10069 | LYN-1604 2HCl | ULK |
| LYN1604 | ||
| LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. | ||
| M13576 | LYN-1604 dihydrochloride | ULK |
| LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC). | ||
| M13577 | MRT68921 dihydrochloride | ULK |
| MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. | ||
| M14590 | MRT67307 | IκB/IKK |
| MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells. | ||
| M21031 | BL-918 | ULK |
| BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1) with EC50 of 24.14 nM and Kd of 0.719 μM. BL-918 induces cytoprotective autophagy for Parkinson's disease. | ||
| M21036 | SBP-7455 | ULK |
| SBP-7455 is a dual-Specific ULK1/2 autophagy inhibitor with IC50s of 13 nM and 476 nM for ULK1 and ULK2 in ADP-Glo assay, respectively. | ||
| M27908 | MRT68921 | ULK |
| MRT68921 is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. | ||
| M28639 | Bizine | Histone demethylase |
| Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>Ki of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine shows neuroprotective effects. | ||
| M29440 | TL12-186 | PROTAC |
| TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM). | ||
| M29821 | HS-276 | IRAK |
| HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research. | ||
| M49490 | 3MB-PP1 | PLK |
| 3MB-PP1 is a bulky purine analog and inhibitor of Polo-like kinase 1 (Plk1) that blocks mitotic progression and cytokinesis by targeting Plk1 in cells expressing the analog-sensitive Plk1 allele. 3MB-PP1 also specifically inhibits the activity of Leu93 mutant Zipper-interacting Ssn3 (Cdk8). 3MB-PP1 inhibits the activity of Leu93 mutant Zipper-interacting Ssn3 (Cdk8). In addition, 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits the Leu93 mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used in the mycelium of Candida albicans. 3MB-PP1 can be used in studies related to mycelium formation and cell division in Candida albicans. | ||
| M49824 | AA-T3A-C12 | Liposome |
| AA-T3A-C12 is an anisamide ligand-bolus lipidoid (AA-lipidoid) that can be used to mediate bulk RNA delivery and transfection of activated fibroblasts. | ||
| M54805 | DCC-3116 | ULK |
| DCC3116 | ||
| DCC-3116 is a first-in-class, potent and selective inhibitor of ULK1/2 kinases and autophagy. ULK1/2 are kinases that receive and process input from nutrient and stress sensors to initiate autophagy. | ||
| M55913 | DCC-3116 | ULK |
| DCC-3116 is an orally active ULK1/2 inhibitor. | ||
| M58486 | XST-14 | ULK |
| XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 has antitumor effects. | ||
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