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MRT68921 dihydrochloride

Cat. No. M13577
MRT68921 dihydrochloride Structure
Size Price Availability Quantity
5mg USD 72  USD72 In stock
10mg USD 120  USD120 In stock
25mg USD 245  USD245 In stock
50mg USD 440  USD440 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 507.5
Formula
CAS Number 2080306-21-2
Purity >99%
Solubility Water 31.25 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Irene Benito-Cuesta, et al. Autophagy. AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance

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Keywords: MRT68921 dihydrochloride supplier, ULK, inhibitors

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