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LYN-1604 dihydrochloride

Cat. No. M13576
LYN-1604 dihydrochloride Structure
Size Price Availability Quantity
5mg USD 142  USD142 In stock
10mg USD 248  USD248 In stock
25mg USD 430  USD430 In stock
50mg USD 700  USD700 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 657.54
Formula
CAS Number 2310109-38-5
Purity >99%
Solubility Water 50 mg/mL
DMSO 50 mg/mL
Storage 2-8°C, dry, sealed
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  Catalog
Abmole Inhibitor Catalog




Keywords: LYN-1604 dihydrochloride supplier, ULK, inhibitors

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