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ULK-101

Cat. No. M10323
ULK-101 Structure
Synonym:

ULK101

Size Price Availability Quantity
2mg USD 188  USD188 In stock
5mg USD 410  USD410 In stock
10mg USD 720  USD720 In stock
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Quality Control
Biological Activity

ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 460.45
Formula C22H16F4N4OS
CAS Number 2443816-45-1
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
References

[1] Katie R Martin, et al. iScience. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress

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  Catalog
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Keywords: ULK-101, ULK101 supplier, ULK, inhibitors

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