About 30 results found for searched term "TC 1" (0.01 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1771 | Ataluren | CFTR |
| PTC124 | ||
| Ataluren (PTC124) is a novel, orally available small molecular CFTR-G542X nonsense allele inhibitor. | ||
| M2214 | JTC-801 | Opioid Receptor |
| JTC-801 is a novel opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM. | ||
| M2572 | SMI-4a | Pim |
| TCS PIM-1 4a; 327033-36-3 | ||
| SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases. | ||
| M2785 | JNK Inhibitor IX (SC202671) | JNK |
| TCS JNK 5a; SC-202671 | ||
| JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. | ||
| M3189 | TCN-201 | GluR |
| TCN201 | ||
| TCN 201 is a NMDA receptor antagonist for NR1/NR2A and NR1/NR2B with pIC50 of 6.8 and 4.3, respectively. | ||
| M3570 | Candesartan Cilexetil | ATM/ATR |
| TCV-116 | ||
| Candesartan Cilexetil is a specific nonpeptide Ang II receptor (ATR) antagonist and the procompound of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg. | ||
| M3745 | TCS PIM-1 1 | Pim |
| SC 204330 | ||
| TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s > 20,000 nM). | ||
| M3760 | TCS-1102 | OX Receptor |
| TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). | ||
| M3801 | TCS 21311 | JAK |
| TCS 21311 is a potent JAK3 inhibitor with IC50 of 8 nM. | ||
| M5207 | Bempedoic acid (ETC-1002) | AMPK |
| ESP-55016; Bempedoic acid | ||
| Bempedoic acid (ETC-1002) is a novel, first-in-class, orally available ATP-citrate lyase (ACL) inhibitor, Bempedoic acid (ETC-1002) can activate AMPK. | ||
| M6150 | GPR39-C3 | GPR/FFAR |
| TC-G-1008 | ||
| GPR39-C3 is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively. | ||
| M6472 | ATC 0175 hydrochloride | Others |
| ATC 0175 hydrochloride is a mCH 1 antagonist; also 5-HT 2B antagonist and 5-HT 1A partial agonist. | ||
| M7358 | TC 1 | Others |
| TC 1 is a high affinity σ 1 ligand. | ||
| M7360 | TC ASK 10 | p38 MAPK |
| TC ASK 10 is a potent and selective ASK1 inhibitor; orally bioavailable. | ||
| M7361 | TC Mps1 12 | Others |
| TC Mps1 12 is a potent and selective Mps1 kinase inhibitor. | ||
| M7362 | TC NTR1 17 | Others |
| TC NTR1 17 is a selective NTS 1 partial agonist. | ||
| M7363 | TC-A 2317 hydrochloride | Others |
| TC-A 2317 hydrochloride is a potent, selective Aurora kinase A inhibitor. | ||
| M7371 | TC-G 1001 | Others |
| TC-G 1001 is a gPR35 agonist; more potent than zaprinast. | ||
| M7372 | TC-G 1003 | Somatostatin Receptor |
| TCG1003 | ||
| TC-G 1003 is a high affinity somatostatin sst2 receptor agonist. | ||
| M7373 | TC-G 1004 | Others |
| TC-G 1004 is a potent and selective A 2A antagonist. | ||
| M7374 | TC-H 106 | HDAC |
| Pimelic Diphenylamide 106; RGFA-8; Histone Deacetylase Inhibitor VII | ||
| TC-H 106 is a class I histone deacetylase inhibitor, with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively. | ||
| M7376 | TC-I 2014 | Others |
| TC-I 2014 is a potent TRPM8 antagonist. | ||
| M7381 | TCS 1105 | Others |
| TCS 1105 is a gABA A α2 benzodiazepine receptor agonist. | ||
| M7382 | TCS 1205 | Others |
| TCS 1205 is a subtype-selective GABA A receptor agonist. | ||
| M7384 | TCS 2314 | Integrin |
| TCS 2314 is a α 4β 1 (VLA-4) antagonist. | ||
| M7385 | TCS 2510 | Prostaglandin Receptor |
| CAY10598; TCS2510 | ||
| TCS 2510 is a selective EP4 agonist. | ||
| M7387 | TCS 5861528 | TRP Channel |
| Chembridge-5861528 | ||
| TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. | ||
| M7388 | TC-S 7001 | ROCK |
| ROCK inhibitor; TC-S 7001 | ||
| TC-S 7001 is a potent and highly selective ROCK inhibitor; orally active. | ||
| M7393 | TC-S 7010 | Others |
| TC-S 7010 is a potent and selective Aurora kinase A inhibitor. | ||
| M7397 | TCS PrP Inhibitor 13 | Others |
| TCS PrP Inhibitor 13 is a antiprion agent; inhibits PrP Sc accumulation. | ||
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