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TC-S 7010 is a potent and selective inhibitor of Aurora kinase A (IC50 = 3.4 nM); exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC50 values are 0.19 and 2.9 μM respectively).
| Molecular Weight | 588.07 |
| Formula | C31H31ClFN7O2 |
| CAS Number | 1158838-45-9 |
| Solubility (25°C) | DMSO 58.81 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Abu-Dalu, et al. Eur J Pharmacol. The actions of ketotifen on intestinal smooth muscles.
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