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TCS 21311

Cat. No. M3801
TCS 21311 Structure
Size Price Availability
5mg USD 135  USD150 Out of stock
10mg USD 198  USD220 Out of stock
50mg USD 792  USD880 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

TCS 21311 is selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). TCS 21311 also inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 526.51
Formula C27H25F3N4O4
CAS Number 1260181-14-3
Purity >98%
Solubility DMSO
Storage at -20°C
References

Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.
Thoma G, et al. J Med Chem. 2011 Jan 13;54(1):284-8. PMID: 21155605.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TCS 21311 supplier, JAK, inhibitors

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