About 30 results found for searched term "SN 2" (0.038 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1791 | Entinostat (MS-275) | HDAC |
| SNDX-275, MS-27-275 | ||
| Entinostat (MS-275) is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively. | ||
| M2003 | PF-04929113 | HSP |
| SNX-5422 | ||
| PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with Kd of 41 nM. SNX-5422 (PF-04929113) also induces Her-2 degradation, with an IC50 of 37 nM. | ||
| M2065 | SNS-032 | CDK |
| BMS-387032 | ||
| SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 9, 2 and 7 with IC50 values of 4, 38 and 62 nM respectively. | ||
| M3211 | Ondansetron | 5-HT Receptor |
| SN 307; GR 38032F; GR-C507/75 | ||
| Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. | ||
| M3528 | SNX-2112 | HSP |
| PF-04928473 | ||
| SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. | ||
| M3771 | PSN632408 | GPR/FFAR |
| PSN632408 is a novel, selective and small-molecule agonist of human and mouse GPR119 with EC50 values of 5.6±0.99 μM and 7.9±0.7 μM, respectively. | ||
| M3989 | Vosaroxin | Topoisomerase |
| SNS-595,AG 7352; Voreloxin | ||
| Vosaroxin is a novel first-in-class quinolone derivative that has been developed for use in the treatment of AML as a new-generation topo II inhibitor. | ||
| M7313 | SN 2 | Others |
| SN 2 is a selective TRPML3 channel activator. | ||
| M7959 | Neuromedin B | Metabolite/Endogenous Metabolite |
| Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2; GNLWATGHFM-NH2 | ||
| Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals. Bombesin-like peptide that is present in the mammalian central nervous system and gastrointestinal tract that has been implicated in the control of food intake, smooth muscle contraction, and thermoregulation. | ||
| M8323 | Dexpramipexole dihydrochloride | Others |
| (R)-Pramipexole dihydrochloride; KNS 760704; SND 919CL2X | ||
| Dexpramipexole dihydrochloride (R-(+)-Pramipexole) is a neuroprotective agent; weak non-ergoline dopamine agonist. | ||
| M8683 | Vosaroxin hydrochloride | Topoisomerase |
| SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride; Voreloxin Hydrochloride | ||
| Vosaroxin hydrochloride is a novel quinolone derivative and first-in-class topoisomerase II inhibitor for AML-related studies. | ||
| M10565 | Kisspeptin-10, human TFA | Peptides |
| KP-10; Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 | ||
| Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis, it acts as a tumor metastasis suppressor via its receptor GPR54. | ||
| M10740 | Gusacitinib | JAK |
| ASN-002 | ||
| Gusacitinib (ASN-002) is a potent dual inhibitor of SYK kinase and JAK kinase,IC50 Values are 5-46 nM. Gusacitinib has anti-cancer activity in both solid and hematological tumors. | ||
| M10746 | Denifanstat | FAS |
| TVB-2640; FASN-IN-2; ASC-40 | ||
| Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research. | ||
| M10896 | Vecabrutinib | BTK |
| SNS-062 | ||
| Vecabrutinib (SNS-062) is a potent, non-covalent BTK and ITK inhibitor,Kd The values are 0.3 nM and 2.2 nM, respectively. Vecabrutinib for ITK IC50 The value is 24 nM. | ||
| M13600 | Abemaciclib metabolite M20 | CDK |
| LSN3106726 | ||
| Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer. | ||
| M13602 | Abemaciclib metabolite M18 hydrochloride | CDK |
| LSN3106729 hydrochloride | ||
| Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader. | ||
| M14876 | THAL-SNS-032 | PROTAC |
| THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). | ||
| M20957 | Cevimeline | AChR/AChE |
| AF 102B; SNI 2011; SNK 508 | ||
| Cevimeline (AF 102B, SNI 2011, SNK 508) is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. | ||
| M24857 | Berlimatoxumab | Others |
| ASN-2 | ||
| Berlimatoxumab (ASN-2) is an antibody. Berlimatoxumab can be used for experiment research. | ||
| M24957 | Axatilimab | CSF-1R (c-Fms) |
| SNDX-6352 | ||
| Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases. | ||
| M25407 | SN52 | NF-κB |
| SN-52 | ||
| SN52 is a novel potent, competitive, and cell-permeable inhibitor of nuclear factor-kappaB (NF-κB). SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. | ||
| M27738 | SNT-207707 | Melanocortin Receptor |
| SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. | ||
| M27755 | SNX-0723 | HSP |
| SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM. | ||
| M27798 | SNT-207858 | Melanocortin Receptor |
| SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. | ||
| M27800 | SNT-207858 free base | Melanocortin Receptor |
| SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. | ||
| M28101 | BTK IN-1 | BTK |
| SNS062 analog | ||
| BTK IN-1 (SNS062 analog) is a potent BTK inhibitor, with an IC50 of <100 nM. | ||
| M28640 | MSN-125 | Bcl-2 |
| MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity. | ||
| M29037 | LSN 3213128 | Antifolate |
| LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity. | ||
| M40557 | SNX281 | STING |
| SNX281 is a STING1 agonist that can be used in studies related to solid tumors. | ||
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