Free shipping on all orders over $ 500

LSN 3213128 

Cat. No. M29037

All AbMole products are for research use only, cannot be used for human consumption.

LSN 3213128  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity.

Chemical Information
Molecular Weight 409.46
Formula C17H16FN3O4S2
CAS Number 1941211-99-9
Form Solid
Solubility (25°C) DMSO 62.5 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kevin R Fales, et al. J Med Chem. Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhi䲧瘀Ỵ瘁㧀痿羹皘的ࡍţࡍĀ�皚嶁皖Ѐ

Related Antifolate Products
Folinic acid calcium salt

Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended

Sulfamethazine

Sulfamethazine is a sulfonamide antibacterial.

Pralatrexate

Pralatrexate is an antifolate, and structurally a folate analog. It acts as an inhibitor of dihydrofolate reductase. It is selective for the reduced folate carrier type 1. Its IC50 is < 300 nM in some cell lines.

Folinic acid calcium salt pentahydrate

Folinic Acid pentahydrate is a reduced form of Folinic Acid that can be used in combination with other chemotherapy-like compounds. *The compound is unstable in solutions, freshly prepared is recommended

Levomefolate calcium

Levomefolate is an artificial form of folate.

  Catalog
Abmole Inhibitor Catalog




Keywords: LSN 3213128  supplier, Antifolate, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.