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SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
| Molecular Weight | 616.62 |
| Formula | C32H43Cl2N5O3 |
| CAS Number | 1104662-66-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Weitao Wang, et al. Semin Plast Surg. Free-Flap Reconstruction of Skull Base and Orbital Defects
[4] Martin Bröring, et al. Chem Commun (Camb). Free-base tripyrrins
[5] M Perez-Reyes, et al. Clin Pharmacol Ther. Free-base cocaine smoking
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CRN04894 is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion. |
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BMS-470539 is a synthetic MC-1R agonist with potent anti-inflammatory properties. |
| PF-00446687
PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM. |
| BMS-470539 dihydrochloride
BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC50 of 120 nM, an EC50 of 28 nM. |
| Undecylenoyl phenylalanine
Undecylenoyl phenylalanine is an antagonist for α-melanocyte-stimulating hormone (MSH) and β-adrenergic receptor (β-ADR) to reduce the melanogenesis in melanocytes. |
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