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Bremelanotide Acetate

Cat. No. M10063
Bremelanotide Acetate Structure
Synonym:

PT-141 Acetate

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Bremelanotide Acetate (PT-141 Acetate) is a peptide containing seven amino acids and is also a macrocyclic compound. In addition, Bremelanotide Acetate is an agonist of the melanocortin 4 receptor (MC4R).

Chemical Information
Molecular Weight 1085.22
Formula C52H72N14O12
CAS Number 1607799-13-2
Solubility (25°C) DMSO 35 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anita H Clayton, et al. Womens Health (Lond). Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial

[2] James G Pfaus, et al. Proc Natl Acad Sci U S A. Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist

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Keywords: Bremelanotide Acetate, PT-141 Acetate supplier, Melanocortin Receptor, inhibitors, activators


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