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Gusacitinib

Cat. No. M10740
Gusacitinib Structure
Synonym:

ASN-002

Size Price Availability Quantity
25mg USD 196  USD245 In stock
50mg USD 356  USD445 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Gusacitinib (ASN-002) is a potent dual inhibitor of SYK kinase and JAK kinase,IC50 Values are 5-46 nM. Gusacitinib has anti-cancer activity in both solid and hematological tumors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 460.53
Formula C24H28N8O2
CAS Number 1425381-60-7
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Michelle Le, et al. Front Med (Lausanne). Systematic Review on the Efficacy and Safety of Oral Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis

[2] A M Cartron, et al. Clin Exp Dermatol. Janus kinase inhibitors for atopic dermatitis: a promising treatment modality

[3] Celina Dubin, et al. Ther Clin Risk Manag. Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges

[4] Krzysztof Szalus, et al. Microorganisms. JAK-STAT Inhibitors in Atopic Dermatitis from Pathogenesis to Clinical Trials Results

[5] Ana M Montilla, et al. Dermatol Ther (Heidelb). Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata

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  Catalog
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Keywords: Gusacitinib, ASN-002 supplier, JAK, inhibitors

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