About 25 results found for searched term "SAG" (0.069 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3361 | Rasagiline Mesylate | Monoamine Oxidase |
| TVP-1012 | ||
| Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. | ||
| M4450 | Acteoside | PKC |
| Verbascoside; Kusaginin; TJC160 | ||
| Acteoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. | ||
| M4865 | Smoothened Agonist (SAG) HCl | Smo |
| SAG.HCl; 912545-86-9 | ||
| Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. | ||
| M7243 | SAG 21k | Others |
| SAG 21k is a hedgehog signaling activator; brain penetrant and orally bioavailable. | ||
| M8027 | Brexanolone | GABA Receptor |
| Allopregnanolone; 3α,5α-THP; SAGE-547; 5α-Pregnan-3α-ol-20-one | ||
| Brexanolone (Allopregnanolone) is a positive allosteric modulator of GABAA chloride channel. | ||
| M8261 | TVP1022 | Monoamine Transporter |
| (S)-Rasagiline; S-PAI | ||
| TVP1022, an S isomer of Rasagiline, an anti-Parkinson's compound, appears to have the same neuroprotective activity as r isomer, but is 1000 times more active as an inhibitor of MAO-B. | ||
| M8514 | Tesaglitazar | Others |
| Tesaglitazar is a potent and specific dual PPARα/γ agonist that improves insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats. | ||
| M10326 | Zuranolone | GABA Receptor |
| SAGE-217; CS-2797; BIIB125 | ||
| Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors. | ||
| M11078 | Sagittatoside A | Others |
| Icariin-A | ||
| Sagittatoside A is a natural compound extracted from the plant Epimedium. | ||
| M11079 | Sagittatoside B | Others |
| Sagittatoside B is a natural compound extracted from the plant Epimedium. | ||
| M14568 | Rasagiline | Monoamine Oxidase |
| (R)-AGN1135; TVP1012 | ||
| Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively. | ||
| M14925 | Hh-Ag1.5 | Hedgehog |
| SAg1.5 | ||
| Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure. | ||
| M14928 | SAG | Smo |
| SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo. | ||
| M14929 | SAG dihydrochloride | Smo |
| SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo. | ||
| M16116 | Kokusaginine | Alkaloids |
| Kokusaginine | ||
| M18442 | Iso-sagittatoside A | Others |
| Iso-sagittatoside A | ||
| M21052 | SAGE-718 | GluR |
| Dalzanemdor | ||
| Dalzanemdor (SAGE-718) is an oral N-methyl-d-aspartate receptor (NMDAR) Positive Allosteric Modulator (PAM) being developed for cognitive impairment in Huntington’s disease. | ||
| M24822 | Tisagenlecleucel | Others |
| CTL019 | ||
| Tisagenlecleucel (CTL019) is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. Tisagenlecleucel targets and eliminates CD19-expressing B cells. Tisagenlecleucel can be used for the research of refractory aggressive diffuse large B-cell lymphoma. | ||
| M28031 | Mipsagargin | Drug-Linker Conjugates for ADC |
| G-202 | ||
| Mipsagargin (G-202) is a novel thapsigargin-based targeted proagent consisting of a prostate-specific membrane antigen (PSMA)-specific peptide coupled to an analog of the potent sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump inhibitor Thapsigargin. Mipsagargin is activated by PSMA-mediated cleavage of an inert masking peptide. Mipsagargin has the potential for refractory, advanced or metastatic solid tumours research. | ||
| M28647 | Napsagatran hydrate | Thrombopoietin/Thrombin |
| Ro 46-6240 hydrate; Ro 46-6240/010 hydrate | ||
| Napsagatran hydrate is a novel and specific thrombin inhibitor. | ||
| M40015 | Sagittatoside C | Others |
| Sagittatoside C is a flavonoid isolated from Herba Epimedii. | ||
| M40474 | Sageone | Others |
| Sageone, a diterpene that can be isolated from Rosmarinus officinalis, is a antiviral and anticancer agent. | ||
| M43253 | Aβ1-14-εK-HBsAg3 Th | Others |
| Aβ1-14-εK-HBsAg3 Th (UB311 immunogen II) is a biological active peptide. | ||
| M51364 | Galanin message associated peptide (1-41) amide | Others |
| Galanin message associated peptide (1-41) amide is a peptide hormone. | ||
| M56996 | Sagopilone | Others |
| Sagopilone (ZK-EPO) demonstrated antitumor activity in human orthotopic glioma models both in vitro and in vivo. | ||
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