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Mipsagargin

Cat. No. M28031

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Mipsagargin Structure
Synonym:

G-202

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Quality Control & Documentation
Biological Activity

Mipsagargin (G-202) is a novel thapsigargin-based targeted proagent consisting of a prostate-specific membrane antigen (PSMA)-specific peptide coupled to an analog of the potent sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump inhibitor Thapsigargin. Mipsagargin is activated by PSMA-mediated cleavage of an inert masking peptide. Mipsagargin has the potential for refractory, advanced or metastatic solid tumours research.

Chemical Information
Molecular Weight 1409.52
Formula C66H100N6O27
CAS Number 1245732-48-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] John T Isaacs, et al. Molecules. Mipsagargin: The Beginning-Not the End-of Thapsigargin Prodrug-Based Cancer Therapeutics

[2] Tomáš Zimmermann, et al. Biomolecules. Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8- O-(12-Aminododecanoyl)-8- O-Debutanoylthapsigargin

[3] D Mahalingam, et al. Br J Cancer. Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours

[4] Trine Bundgaard Andersen, et al. Molecules. Thapsigargin--from Thapsia L. to mipsagargin

[5] Nhu Thi Quynh Doan, et al. Steroids. Targeting thapsigargin towards tumors

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Keywords: Mipsagargin, G-202 supplier, Drug-Linker Conjugates for ADC, inhibitors, activators

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