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Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors. Zuranolone shows >30 μM inhibition in a cardiac panel of eight relevant cardiac ion channels. In vivo, Zuranolone (0.3-5 mg/kg, i.v.) in the rat model of status epilepticus (SE) abolishes both behavioral and electrographic seizure activity, even when administered 60 min after induction of SE. Additional PK studies of Zuranolone in dog show low clearance (<10% of hepatic blood flow), resulting in excellent 68% oral bioavailability.
| Molecular Weight | 409.56 |
| Formula | C25H35N3O2 |
| CAS Number | 1632051-40-1 |
| Solubility (25°C) | DMSO 82 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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