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Rasagiline

Cat. No. M14568
Rasagiline Structure
Synonym:

(R)-AGN1135; TVP1012

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Biological Activity

Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively.

Chemical Information
Molecular Weight 171.24
CAS Number 136236-51-6
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Masahiro Nagai, et al. [Pharmacological properties and clinical efficacy of rasagiline mesylate (Azilect ®)]

[2] No authors listed. Rasagiline

[3] No authors listed. Rasagiline

[4] C Warren Olanow, et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease

[5] M Asif A Siddiqui, et al. Rasagiline

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  Catalog
Abmole Inhibitor Catalog




Keywords: Rasagiline, (R)-AGN1135; TVP1012 supplier, Monoamine Oxidase, inhibitors, activators


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