All AbMole products are for research use only, cannot be used for human consumption.
SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.
J Vis Exp. 2025 Jan 31;Jan 31:(215).
Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Smoothened Agonist (SAG) HCl purchased from AbMole
Front Mol Biosci. 2023 Nov 23;10:1268722.
Paralog-specific TTC30 regulation of Sonic hedgehog signaling
Smoothened Agonist (SAG) HCl purchased from AbMole
| Molecular Weight | 526.52 |
| Formula | C28H29Cl2N3OS |
| CAS Number | 2095432-58-7 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[1] Chen JK, et.al. Proc Natl Acad Sci U S A. Small molecule modulation of Smoothened activity.
| Related Smo Products |
|---|
| Glasdegib Maleate
Glasdegib Maleate is an orally bioavailable Smoothened (Smo) inhibitor with an IC50 value of 4 nM for studies related to acute myeloid leukemia. |
| MRT-81
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer. |
| Fluticasone
Fluticasone is a corticosteroid and Smo agonist with an IC50 of 99 nM, which activates the Hedgehog signaling pathway and promotes the proliferation of primary neural stem or precursor cells, and can be used in respiratory related studies. |
| HhAntag
HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway. |
| PF-5274857 hydrochloride
PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
