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Smoothened Agonist (SAG) HCl

Cat. No. M4865
Smoothened Agonist (SAG) HCl Structure
Synonym:

SAG.HCl; 912545-86-9

Size Price Availability Quantity
10mM*1mL in DMSO USD 135  USD135 In stock
1mg USD 55  USD55 In stock
5mg USD 110  USD110 In stock
10mg USD 180  USD180 In stock
25mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.

Product Citations
Chemical Information
Molecular Weight 526.52
Formula C28H29Cl2N3OS
CAS Number 2095432-58-7
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chen JK, et.al. Proc Natl Acad Sci U S A. Small molecule modulation of Smoothened activity.

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Keywords: Smoothened Agonist (SAG) HCl, SAG.HCl; 912545-86-9 supplier, Smo, inhibitors, activators


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