|M14929||SAG dihydrochloride||SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.|
|M14928||SAG||SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.|
|M11272||KAAD-Cyclopamine||Kaad-cyclopamine is an inhibitor of hedgehog signaling pathway and an antagonist of Smoothened.|
|M10835||Saridegib||Saridegib is a specific and effective inhibitor of Smo, a key transmembrane signaling protein in the Hedgehog pathway.|
|M9205||Glasdegib||Glasdegib (PF-04449913) is a potent, orally bioavailable Smoothened (Smo) inhibitor with an IC50 of 4 nM.|
|M8977||MK-4101||MK-4101 is a novel SMO antagonist of the Hedgehog Pathway.|
|M2997||SANT-1||SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.|
|M2465||BMS-833923||BMS-833923 is an orally bioavailable Smoothened antagonist.|
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