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Purmorphamine

Cat. No. M1874
Purmorphamine Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 60  USD60 In stock
5mg USD 110  USD110 In stock
10mg USD 160  USD160 In stock
25mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

Purmorphamine is a small molecule Hh agonist, it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway. Hedgehog agonist purmorphamine most significantly increased the neuronal differentiation of a human striatal NSC line (STROC05). Purmorphamine up-regulated gene expression of the mediators of Hh pathway, SMO, PTCH1, GLI1, and GLI2. The activation of Hh pathway by purmorphamine increased the expression of several genes. Purmorphamine triggers Hh signaling pathway in hMSCs, inducing an increase in the expression of a set of genes involved in the osteoblast differentiation program. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.

Chemical Information
Molecular Weight 520.6
Formula C31H32N6O2
CAS Number 483367-10-8
Solubility (25°C) DMSO 4 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] S Rahi, et al. Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism

[2] Dexiang Liu, et al. Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

[3] Maryam Rezia Rad, et al. Purmorphamine increased adhesion, proliferation and expression of osteoblast phenotype markers of human dental pulp stem cells cultured on beta-tricalcium phosphate

[4] Mrcio M Beloti, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells

[5] Xu Wu, et al. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

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Keywords: Purmorphamine supplier, Smo, inhibitors, activators


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