Cat.No. | Name | Information |
---|---|---|
M1713 | GDC-0449 (Vismodegib) | GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. |
M4865 | Smoothened Agonist (SAG) HCl | Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. |
M27940 | LEQ506 | LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. |
M14929 | SAG dihydrochloride | SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo. |
M11272 | KAAD-Cyclopamine | Kaad-cyclopamine is an inhibitor of hedgehog signaling pathway and an antagonist of Smoothened. |
M10835 | Saridegib | Saridegib is a specific and effective inhibitor of Smo, a key transmembrane signaling protein in the Hedgehog pathway. |
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