Smo Smoothened

Cat.No.	Name	Information
M1713	GDC-0449 (Vismodegib)	GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively.
M4865	Smoothened Agonist (SAG) HCl	Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
M4841	LDE225 (Sonidegib) diphosphate	LDE225 Diphosphate (Sonidegib diphosphate) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
M28238	ALLO-2	ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
M27940	LEQ506	LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.
M14929	SAG dihydrochloride	SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
M11272	KAAD-Cyclopamine	Kaad-cyclopamine is an inhibitor of hedgehog signaling pathway and an antagonist of Smoothened.
M10835	Saridegib	Saridegib is a specific and effective inhibitor of Smo, a key transmembrane signaling protein in the Hedgehog pathway.