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LEQ506

Cat. No. M27940

All AbMole products are for research use only, cannot be used for human consumption.

LEQ506 Structure
Synonym:

NVP-LEQ506

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Quality Control & Documentation
Biological Activity

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.

Chemical Information
Molecular Weight 432.56
Formula C25H32N6O
CAS Number 1204975-42-7
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jing Tu, et al. Pharmacol Res. Molecular modeling study on resistance of WT/D473H SMO to antagonists LDE-225 and LEQ-506

[2] Emilie Lauressergues, et al. Pharmacol Res Perspect. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model

[3] Stefan Peukert, et al. ChemMedChem. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened

[4] Jean Y Tang, et al. Semin Cutan Med Surg. Emerging treatments and signaling pathway inhibitors

Related Smo Products
20α-Hydroxycholesterol

20α-Hydroxycholesterol is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20α-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors. 20α-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells.

Glasdegib Maleate

Glasdegib Maleate is an orally bioavailable Smoothened (Smo) inhibitor with an IC50 value of 4 nM for studies related to acute myeloid leukemia.

MRT-81 

MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.

Fluticasone

Fluticasone is a corticosteroid and Smo agonist with an IC50 of 99 nM, which activates the Hedgehog signaling pathway and promotes the proliferation of primary neural stem or precursor cells, and can be used in respiratory related studies.

HhAntag 

HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway.

  Catalog
Abmole Inhibitor Catalog




Keywords: LEQ506, NVP-LEQ506 supplier, Smo, inhibitors, activators

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