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KAAD-Cyclopamine

Cat. No. M11272
KAAD-Cyclopamine Structure
Synonym:

Cyclopamine-KAAD

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Quality Control
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  • Purity N/A
  • COA
  • MSDS
Biological Activity

Kaad-cyclopamine is an inhibitor of hedgehog signaling pathway and an antagonist of Smoothened.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 697.99
Formula C44H63N3O4
CAS Number 306387-90-6
Purity N/A
Solubility N/A
Storage at -20°C
References

[1] Bin Chen, et al. Turk J Gastroenterol. Effects and mechanism of Lanthanum Citrate on the proliferation and apoptosis of hepatocellular carcinoma cell line SMMC-7721

[2] Paweł Kozielewicz, et al. Mol Pharmacol. A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine

[3] Stephen T Lee, et al. J Pharm Biomed Anal. Development of a monoclonal antibody-based ELISA for the hedgehog inhibitors cyclopamine and KAAD-cyclopamine

[4] Nanor Sirab, et al. Int J Cancer. Androgens regulate Hedgehog signalling and proliferation in androgen-dependent prostate cells

[5] Markus David Siegelin, et al. Neurobiol Dis. KAAD-cyclopamine augmented TRAIL-mediated apoptosis in malignant glioma cells by modulating the intrinsic and extrinsic apoptotic pathway

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Keywords: KAAD-Cyclopamine, Cyclopamine-KAAD supplier, Smo, inhibitors

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