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GSA-10 is a novel, potent activator of the smoothened receptor (Smo). GSA-10 acts on Smo to promote the differentiation of pluripotent mesenchymal stem cells into osteoblasts with an EC50 of 1.2 μM. GSA-10 binds to Smo at a unique site compared to agonists such as SAG and purmorphamine, and is not affected by the Smo antagonist cyclopamine. GSA-10 promotes the differentiation of mesenchymal pluripotent C3H10T1/2 cells into osteoblasts.
| Molecular Weight | 450.53 |
| Formula | C26H30N2O5 |
| CAS Number | 300833-95-8 |
| Solubility (25°C) | DMSO: 0.5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Smo Products |
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| 20α-Hydroxycholesterol
20α-Hydroxycholesterol is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20α-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors. 20α-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells. |
| Glasdegib Maleate
Glasdegib Maleate is an orally bioavailable Smoothened (Smo) inhibitor with an IC50 value of 4 nM for studies related to acute myeloid leukemia. |
| MRT-81
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer. |
| Fluticasone
Fluticasone is a corticosteroid and Smo agonist with an IC50 of 99 nM, which activates the Hedgehog signaling pathway and promotes the proliferation of primary neural stem or precursor cells, and can be used in respiratory related studies. |
| HhAntag
HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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