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TVP1022, an S isomer of Rasagiline, an anti-Parkinson's compound, appears to have the same neuroprotective activity as r isomer, but is 1000 times more active as an inhibitor of MAO-B. TVP1022 is a neuroprotective and cellular protective molecule that also has cardioprotective effects in rat models. Its activity is thought to involve stabilizing mitochondrial membrane potential, inducing activation of bcl-2 and PKC signaling pathways, and enhancing phosphorylation of protein kinase C and glycogen synthase kinase 3β.
| Molecular Weight | 171.24 |
| Formula | C12H13N |
| CAS Number | 185517-74-2 |
| Solubility (25°C) | DMSO: ≥15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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