Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M31235 | 13-Hydroxyisobakuchiol | Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol) is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). |
| M11400 | Valbenazine | Valbenazine (NBI-98854) is a vesicular monoamine transporter-2 (VMAT2) inhibitor with a Ki of 110-190 nM. |
| M3252 | Tetrabenazine | Tetrabenazine (Nitoman, Xenazine) is a compound for the symptomatic treatment of hyperkinetic movement disorder. |
| M42208 | VMAT2-IN-2 tosylate | VMAT2-IN-2 tosylate is a potent VMAT2 inhibitor. |
| M30634 | Tetrabenazine mesylate | Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease. |
| M30533 | Tetrabenazine Racemate | Tetrabenazine Racemate (Ro 1-9569 Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2). (1) The reference for administration is 0.25-0.75 mg/kg IP (2) Injections of tetrabenazine into accumbens core also reduced FR5 lever pressing and increased chow intake. (3) Tetrabenazine (Racemate) reduced extracellular DA and altered DARPP-32 signaling in both substance-P- and enkephalin-containing accumbens neurons. (4) Tetrabenazine (Racemate) inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice. |
| M27659 | (+)-Tetrabenazine | (+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. [2] (+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1] In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2] |
| M11425 | Valbenazine tosylate | Valbenazine Tosylate (NBI-98854 tosylate) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with Ki of 110-190 nM. |
| M8463 | FFN102 | FFN102 is a pH-responsive fluorescent false neurotransmitter that acts as a dopamine transporter substrate (DAT) and also a substrate for vesicular monoamine transporter 2 (VMAT2). |
| M8261 | TVP1022 | TVP1022, an S isomer of Rasagiline, an anti-Parkinson's compound, appears to have the same neuroprotective activity as r isomer, but is 1000 times more active as an inhibitor of MAO-B. |
| M6728 | FFN 206 dihydrochloride | FFN 206 dihydrochloride is a fluorescent VMAT2 substrate. |
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