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FFN102

Cat. No. M8463

All AbMole products are for research use only, cannot be used for human consumption.

FFN102 Structure

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Biological Activity

FFN102 is a pH-responsive fluorescent false neurotransmitter that acts as a dopamine transporter substrate (DAT) and also a substrate for vesicular monoamine transporter 2 (VMAT2). FFN102 selectively labels dopamine cell bodies and dendrites in ventral midbrain and dopaminergic synaptic terminals in dorsal striatum. Its greater fluorescence emission in neutral than acidic environments allows the visualization of dopamine release at individual presynaptic terminals and in situ pH measurement of catecholamine secretory vesicles.

Chemical Information
Molecular Weight 353.68
Formula C11H10ClNO3 · CF3CO2H
CAS Number 1234064-11-9
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jozsef Meszaros, et al. Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus

[2] Lihui Hu, et al. Electroactive fluorescent false neurotransmitter FFN102 partially replaces dopamine in PC12 cell vesicles

[3] Xiaoqing Liu, et al. Coupling electrochemistry and TIRF-microscopy with the fluorescent false neurotransmitter FFN102 supports the fluorescence signals during single vesicle exocytosis detection

[4] Xiaoqing Liu, et al. A Dual Functional Electroactive and Fluorescent Probe for Coupled Measurements of Vesicular Exocytosis with High Spatial and Temporal Resolution

[5] Pamela C Rodriguez, et al. Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain

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Keywords: FFN102 supplier, Monoamine Transporter, inhibitors, activators

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