About 30 results found for searched term "PP1" (0.071 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2011 | PP121 | VEGFR/PDGFR |
| PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. | ||
| M2953 | PP1 | Src-bcr-Abl |
| AGL 1872, EI 275 | ||
| PP1 is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM. | ||
| M3147 | PPQ-102 | CFTR |
| CFTR Inhibitor | ||
| PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM. | ||
| M5303 | 1-Naphthyl PP1 | PKC |
| 1-NA-PP 1 | ||
| 1-Naphthyl PP1(1-NA-PP 1) is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). | ||
| M5398 | Aliskiren Hemifumarate | Renin |
| CGP 60536; CGP60536B; SPP 100 | ||
| Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM. | ||
| M9798 | 1NM-PP1 | Src-bcr-Abl |
| 1-NM-PP1; PP1 Analog II | ||
| 1NM-PP1 is a cell-permeable and potent Src family kinases inhibitor with IC50 values of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. | ||
| M10631 | Enpp-1-IN-1 | PDE |
| MV 658; ABM-8589 | ||
| Enpp-1-IN-1, also known as MV 658, is a Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitor. | ||
| M13376 | Abarelix | LHRH/GnRH |
| R3827; PPI 149 | ||
| Abarelix (R3827) is the first approved antagonist for the study of GnRH in advanced prostate cancer. Sequence：Ac-{d-2-Nal}-{d-4-Cpa}-{d-3-Pal}-S-{NMyr}-{d-Asp}-L-K(ipr)-P-{d-Ala}-NH2 | ||
| M13983 | Abarelix Acetate | LHRH/GnRH |
| PPI 149 Acetate; R 3827 Acetate | ||
| Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research. | ||
| M15028 | Recombinant Human NAP-2/CXCL7 (CHO) | Cytokines and Growth Factors |
| PPBP; B-TG1; Beta-TG; CTAP-III | ||
| Neutrophil activating peptide 2 (NAP2) is a carboxy-terminal fragment of platelet basic protein (PBP) found in human platelet α particles. Nap2 is a member of the CXC chemokine. Protein structure: CXCL7 (ALA59-ASP128), Accession # P02775. | ||
| M14530 | Aliskiren | Renin |
| CGP 60536; CGP60536B; SPP 100 | ||
| Aliskiren(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM. | ||
| M14643 | 2OH-BNPP1 | Others |
| 2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer. | ||
| M14909 | 1-Naphthyl PP1 hydrochloride | Src-bcr-Abl |
| 1-NA-PP 1 hydrochloride | ||
| 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively. | ||
| M25440 | Recombinant Human Osteopontin/SPP1 Protein (HEK293, C-6His) | Cytokines and Growth Factors |
| OPN; Secreted Phosphoprotein 1 | ||
| Osteopontin/SPP1 is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Osteopontin/SPP1 acts as a cytokine that is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. | ||
| M25528 | (D) PPA-1 TFA | PD-1/PD-L1 |
| (D) PPA-1 TFA is the first hydrolysisresistant D-peptide antagonists to target the PD-1/PD-L1 pathway. (D) PPA-1 could bind PD-L1 at an affinity of 0.51 μM in vitro. | ||
| M28032 | Ppc-1 | Mitochondrial Related |
| Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities. | ||
| M28069 | THPP-1 | PDE |
| THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species. | ||
| M29740 | Enpp-1-IN-12 | PDE |
| Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity. | ||
| M31384 | TPP-1 hydrochloride | PD-1/PD-L1 |
| TPP-1 hydrochloride is a potent inhibitor of PD-1/PD-L1 interaction and binds specifically to PD-L1 with a Kd value of 95 nM.Can be used in tumor related studies. | ||
| M41101 | PEX5-PEX14 PPI-IN-1 | Antibiotic |
| PEX5-PEX14 PPI-IN-1 is a PEX14-PEX5 PPI inhibitor. | ||
| M42447 | HPPD-IN-1 | Others |
| HPPD-IN-1 is a HPPD inhibitor. | ||
| M42556 | Enpp-1-IN-17 | PDE |
| Enpp-1-IN-17 is a potent ENPP1 inhibitor, with the inhibition constants (Ki values) toward cGAMP and ATP hydrolysis of 100 nM-1 μM and > 1 μM, respectively. | ||
| M42558 | Enpp-1-IN-15 | PDE |
| Enpp-1-IN-15 is an Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (Enpp-1) Inhibitor, with a Ki value of 0.00586 nM. | ||
| M42569 | Enpp-1-IN-16 | PDE |
| Enpp-1-IN-16 is an ENPP1 inhibitor. | ||
| M43598 | SLU-PP-1072 | Estrogen Receptor |
| SLU-PP-1072 is a dual ERRα/γ inverse agonist, used in Prostate cancer (PCa) research. | ||
| M49490 | 3MB-PP1 | PLK |
| 3MB-PP1 is a bulky purine analog and inhibitor of Polo-like kinase 1 (Plk1) that blocks mitotic progression and cytokinesis by targeting Plk1 in cells expressing the analog-sensitive Plk1 allele. 3MB-PP1 also specifically inhibits the activity of Leu93 mutant Zipper-interacting Ssn3 (Cdk8). 3MB-PP1 inhibits the activity of Leu93 mutant Zipper-interacting Ssn3 (Cdk8). In addition, 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits the Leu93 mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used in the mycelium of Candida albicans. 3MB-PP1 can be used in studies related to mycelium formation and cell division in Candida albicans. | ||
| M50859 | CMV pp65(13-27) | Others |
| CMV pp65(13-27) is a biological active peptide. | ||
| M52841 | (D)-PPA 1 | PD-1/PD-L1 |
| (D)-PPA 1 is a hydrolysisresistant d-peptide antagonist. | ||
| M53547 | PP13 | Antibiotic |
| PP13 is an antimicrobial peptide, and is active against Gram-negative and Gram-positive bacteria E.coli (MIC: 16.7 uM), B. | ||
| M54061 | [cPP1-7, NPY19-23, Ala31, Aib32, Gln34]-hPancreatic Polypeptide | Neuropeptide Receptor |
| [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. | ||
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