Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities.
| Molecular Weight | 355.43 |
| Formula | C21H25NO4 |
| CAS Number | 1245818-17-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Mitochondrial Related Products |
|---|
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ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP), with EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. |
| Speract
Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism. |
| BTM-3566
BTM-3566 is an OMA1 activator. |
| Bach1-IN-1
Bach1-IN-1 is a potent Bach1 inhibitor. |
| SCAL-266
SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. |
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