Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M10919 | Mito-TEMPO | Mito-TEMPO (MT) is a mitochondrial-targeted superoxide dismutase mimetic that protects the early stages of acetaminophen (APAP) hepatotoxicity by inhibiting the formation of peroxynitrite. Mito-TEMPO treatment inhibits APAP-induced EXPRESSION OF RIP3 kinase. |
| M9051 | FCCP | FCCP is a mitochondrial uncoupling agent and an oxidative phosphorylation (OXPHOS) inhibitor. FCCP is often used as an apoptosis inducer. |
| M58540 | Mitochondrial fusion promoter M1 | Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 (2 mg/kg; iv) alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury. |
| M58487 | NL-1 | NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50 values of 47.35 μM and 56.26 μM, respectively. |
| M58261 | Malonyl CoA lithium | Malonyl CoA lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). Malonyl Coenzyme A lithium (Malonyl CoA lithium) is an important precursor for the production of a variety of chemicals that modulate insulin-stimulated glucose transport in myotubes. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. |
| M56716 | MFI8 | MFI8 is a small molecule inhibitor of mitochondrial. |
| M55258 | THP104c | THP104c is a mitochondrial fission inhibitor. |
| M54715 | ZK53 | ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP), with EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. |
| M42507 | Bach1-IN-1 | Bach1-IN-1 is a potent Bach1 inhibitor. |
| M40615 | Ferulenol | Ferulenol is a sesquiterpene-based coumarin derivative isolated and purified from Ferula vesceritensis that causes inhibition of oxidative phosphorylation. At low concentrations, it can inhibit ATP synthesis by inhibiting adenine nucleotide translocase, and has pro-oxidant and anti-cancer activities. In addition, Ferulenol also induces specific inhibition of succinate ubiquinone reductase without altering the succinate dehydrogenase activity of complex II. Ferulenol can be used to study the physiological role of mitochondrial complex II and electron transport mechanisms. |
| M31395 | 1-Hexanol | 1-Hexanol is a tertiary alcohol that also acts as a surfactant and uncouples mitochondrial respiration by a nonprotonic mechanism. |
| M22353 | Fumarate hydratase-IN-1 | Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. |
| M21615 | MitoTEMPOL | MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. |
| M21139 | Ninerafaxstat trihydrochloride | Ninerafaxstat trihydrochloride shifts cellular metabolism to glucose oxidation from fatty acid oxidation. Ninerafaxstat trihydrochloride improves overall mitochondrial respiration and reduces fatty acid oxidation, thereby inhibiting the proliferation and growth of cancer cells. |
| M20874 | Elamipretide | Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) is a cytochrome c peroxidase inhibitor. Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. |
| M20774 | CTPI-2 | CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). |
| M14653 | AP39 | AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. |
| M14463 | Afzelin | Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. |
| M11519 | IMT1 | IMT1 is the first, specific and non-competitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 induces conformational changes in POLRMT that block substrate binding and transcription in a dose-dependent manner in vitro. IMT1 reduced deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in significant depletion of cellular amino acid levels. |
| M11226 | VLX600 | VLX600 is a novel inhibitor of iron-chelated oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and can show enhanced cytotoxicity in nutrient deficiency conditions. VLX600 showed selective cytotoxic activity against malignant cells and induced autophagy and had anticancer activity.*The compound is unstable in solutions, freshly prepared is recommended |
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