Free shipping on all orders over $ 500

Fumarate hydratase-IN-1

Cat. No. M22353

All AbMole products are for research use only, cannot be used for human consumption.

Fumarate hydratase-IN-1 Structure
Size Price Availability Quantity
2mg USD 165  USD165 In stock
5mg USD 260  USD260 In stock
10mg USD 360  USD360 In stock
25mg USD 720  USD720 In stock
50mg USD 1120  USD1120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM.

Chemical Information
Molecular Weight 446.54
Formula C27H30N2O4
CAS Number 1644060-37-6
Solubility (25°C) DMSO 45 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Irena Majkutewicz. Eur J Pharmacol. Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases

[2] Julia Paik. CNS Drugs. Diroximel Fumarate in Relapsing Forms of Multiple Sclerosis: A Profile of Its Use

[3] Duvyanshu Dubey, et al. Expert Rev Neurother. Dimethyl fumarate in relapsing-remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety

[4] Celeste B Burness, et al. CNS Drugs. Dimethyl fumarate: a review of its use in patients with relapsing-remitting multiple sclerosis

[5] Take-Aki Mitsudo, et al. Chem Rec. Chemistry of Ru(eta6-1,3,5-cyclooctatriene)(eta2-dimethyl fumarate)2

Related Mitochondrial Related Products
OPC-163493

OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS.

Mitochondrial fusion promoter M1

Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 (2 mg/kg; iv) alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury.

NL-1

NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50 values of 47.35 μM and 56.26 μM, respectively.

Malonyl CoA lithium

Malonyl CoA lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). Malonyl Coenzyme A lithium (Malonyl CoA lithium) is an important precursor for the production of a variety of chemicals that modulate insulin-stimulated glucose transport in myotubes. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.

MFI8 

MFI8 is a small molecule inhibitor of mitochondrial.

  Catalog
Abmole Inhibitor Catalog




Keywords: Fumarate hydratase-IN-1 supplier, Mitochondrial Related, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.