Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M9051 | FCCP | FCCP is a mitochondrial uncoupling agent and an oxidative phosphorylation (OXPHOS) inhibitor. FCCP is often used as an apoptosis inducer. |
| M10919 | Mito-TEMPO | Mito-TEMPO (MT) is a mitochondrial-targeted superoxide dismutase mimetic that protects the early stages of acetaminophen (APAP) hepatotoxicity by inhibiting the formation of peroxynitrite. Mito-TEMPO treatment inhibits APAP-induced EXPRESSION OF RIP3 kinase. |
| M10336 | KL1333 | KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. |
| M9911 | Lixumistat | Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat (IM156) is a metformin derivative, which increases AMPK phosphorylation. |
| M3315 | Thiabendazole | Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. |
| M58607 | OPC-163493 | OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. |
| M56715 | GW604714X | GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. |
| M56714 | Antimalarial agent 14 | Antimalarial agent 14 is a potent inhibitor of mitochondrial electron transport. |
| M55651 | IM176OUT05 | IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM. IM176OUT05 is a high solubility biguanide. |
| M52573 | Speract | Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism. |
| M42508 | BTM-3566 | BTM-3566 is an OMA1 activator. |
| M42506 | SCAL-266 | SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. |
| M42505 | SCAL-255 | SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 1.14 μM. |
| M42504 | ND-011992 | ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. |
| M42503 | GNX-865 | GNX-865 is a mitochondrial permeability transition pore (mPTP) inhibitor that protects against ischemia-reperfusion injury in vivo. |
| M42502 | HP661 | HP661 is an orally available oxidative phosphorylation (OXPHOS) inhibitor that effectively blocks the activity of mitochondrial complex I and reduces the production of the reactive oxygen species. |
| M42501 | Leramistat | Leramistat (HMC-C-01-A; MBS2320) is a mitochondrial complex 1 inhibitor, involving in cell metabolism immune metabolism regulation. |
| M41386 | EP-0035985 | EP-0035985 is an activator of mitophagy. |
| M40980 | HU6 | HU6 is a mitochondrial oxidative phosphorylation uncoupler that can be used in studies related to non-alcoholic steatohepatitis (NASH). |
| M40536 | T0467 | T0467 is a potential PINK1-Parkin signaling activator that activates mitochondrial parkin translocation in a PINK1-dependent manner, but does not induce mitochondrial aggregation of PINK1 in dopaminergic neurons. It can be used in the study of Parkinson's disease and related disorders. |
| M39158 | Genistein 8-c-glucoside | Genistein 8-c-glucoside (G8CG) is a glucoside. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces apoptosis. |
| M31379 | Petasin | Petasin (PT) is a naturally occurring sesquiterpene ester derived from plants and is also a potent mitochondrial electron transport chain complex I (ETCC1) inhibitor with broad-spectrum antitumor activity. |
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