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NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50 values of 47.35 μM and 56.26 μM, respectively.
In vivo, NL-1 (10 mg/kg; intraperitoneal injection; daily; for 5 days) treatment shows antileukemic activity in an female NSG mice ALL model.
| Molecular Weight | 335.46 |
| Formula | C18H25NO3S |
| CAS Number | 188532-26-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 150 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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