All AbMole products are for research use only, cannot be used for human consumption.
Osteopontin/SPP1 is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Osteopontin/SPP1 acts as a cytokine that is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. It is essential in the pathway that leads to type I immunity. Osteopontin has been implicated as an important factor in bone remodeling. Specifically, research suggests it plays a role in anchoring osteoclasts to the mineral matrix of bones. The fact that SPP1 interacts with multiple cell surface receptors which are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation and ischemia.
Recombinant Human Osteopontin/SPP1 is produced by Mammalian expression system and the target gene encoding Ile17-Asn314 is expressed with a 6His tag at the C-terminus.
Accession: P10451
APMol Mass: 60-70 KDa, reducing conditions
Endotoxin: < 1 EU/µg as determined by LAL test
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. |
[1] Itai Rotem, et al. Basic Res Cardiol. Osteopontin promotes infarct repair
Related Recombinant Proteins Products |
---|
Recombinant Human METRNL Protein (E. coli, N-His)
METRNL (Meteorin-like protein) is a hormone, released after physical activity (in skeletal muscle) or exposure to cold (in adipose tissue), that induces energy rate. METRNL stimulates energy rate correlate with white fat browning and raise glucose tolerance. The protein stimulates different types of immune cells to enter the fat tissue and start their prothermogenic actions. |
Recombinant Human HK2 Protein (E. coli, N-His)
Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs). |
Recombinant Human HK2 Protein (Baculovirus-Insect, C-His)
Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs). |
Recombinant Human HER2 Protein (HEK293, C-6His)
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. |
Recombinant Mouse Growth Hormone (E. coli)
Somatotropin (GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.