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THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species.
| Molecular Weight | 464.9 |
| Formula | C23H21ClN6O3 |
| CAS Number | 1257051-63-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 31.25 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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