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1NM-PP1

Cat. No. M9798
1NM-PP1 Structure
Synonym:

1-NM-PP1; PP1 Analog II

Size Price Availability Quantity
10mg USD 175  USD175 In stock
25mg USD 375  USD375 In stock
50mg USD 675  USD675 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

1NM-PP1 is a cell-permeable and potent Src family kinases inhibitor with IC50 values of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 331.41
Formula C20H21N5
CAS Number 221244-14-0
Purity >99%
Solubility DMSO ≥ 17 mg/mL
Storage at -20°C
References

[1] Tatsuki Sugi, et al. J Vet Med Sci. 1NM-PP1 treatment of mice infected with Toxoplasma gondii

[2] Tatsuki Sugi, et al. Eukaryot Cell. Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step

[3] Stephane Larochelle, et al. Mol Cell. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells

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  Catalog
Abmole Inhibitor Catalog




Keywords: 1NM-PP1, 1-NM-PP1; PP1 Analog II supplier, Src-bcr-Abl, inhibitors

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